Physiological Research Antioxidant/Oxidant Status and Cardiac Function in Bradykinin B1- and B2-Receptor Null Mice
نویسندگان
چکیده
COHIRO Biotechnology, Faculty of Medicine, 21000 Dijon France (http://www.cohiro.fr/), Laboratory of Cardio-Metabolic Pathophysiology and Pharmacology (LPPCM), INSERM, U866 , Université de Bourgogne, 21000 Dijon, France, Department of Cardiology, University Hospital, Dijon (21000), France , Institute of Metabolic and Cardiovascular Diseases (I2MC), INSERM, U1048, Université Paul Sabatier, 31432 Toulouse, France, Department of Physiology, Faculty of Medicine, Université de Montréal, Montréal, Qc, Canada H3C 3J7, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany
منابع مشابه
Antioxidant/oxidant status and cardiac function in bradykinin B(1)- and B(2)-receptor null mice.
Kinin-vasoactive peptides activate two G-protein-coupled receptors (R), B(1)R (inducible) and B(2)R (constitutive). Their complex role in cardiovascular diseases could be related to differential actions on oxidative stress. This study investigated impacts of B(1)R or B(2)R gene deletion in mice on the cardiac function and plasma antioxidant and oxidant status. Echocardiography-Doppler was perfo...
متن کاملBradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury.
To explore the role of the kallikrein-kinin system in relation to ischemia/reperfusion injury in the kidney, we generated mice lacking both the bradykinin B1 and B2 receptor genes (B1RB2R-null, Bdkrb1-/-/Bdkrb2-/-) by deleting the genomic region encoding the two receptors. In 4-month-old mice, blood pressures were not significantly different among B1RB2R-null, B2R-null (Bdkrb2-/-), and WT mice....
متن کاملPreparation of a Photoactivable Ligand for Bradykinin Receptors
ABSTRACT Most of physiological effects of bradykinin is due to its effect on bradykinin B2 receptors. There is no reports of preparation of a photoactivatable analogue of bradykinin reactive with sloubilized bradykinin B2 recpetors. Photoactivatable radioactive ligands are powerful tools in purification of receptors. In this study we report preparation of a photoactivatable iodinatable analo...
متن کاملEffects of a Novel Bradykinin B1 Receptor Antagonist and Angiotensin II Receptor Blockade on Experimental Myocardial Infarction in Rats
BACKGROUND The aim of the present study was to evaluate the cardiovascular effects of the novel bradykinin B1 receptor antagonist BI-113823 following myocardial infarction (MI) and to determine whether B1 receptor blockade alters the cardiovascular effects of an angiotensin II type 1 (AT1) receptor antagonist after MI in rats. METHODOLOGY/PRINCIPAL FINDINGS Sprague Dawley rats were subjected ...
متن کاملAngiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice.
Both bradykinin B2 and angiotensin II type 2 (AT2) receptors are known to stimulate renal production of nitric oxide (NO). To evaluate the individual contributions of AT2 and B2 receptors to renal NO production, we monitored renal interstitial, stable NO metabolites and cGMP by a microdialysis technique in conscious, bradykinin B2-null and wild-type mice (n=8 in each group) during low sodium in...
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